The Skolars, who were formed just 11 years ago and became a senior club in 2003, were facing Super League opposition for the first time in a competitive game and gave an excellent account of themselves, but were outclassed throughout.
The Wolves rested a number of senior players and made eight changes from the side that defeated Wakefield in the Super League the previous week, but they did welcome back Stuart Reardon, who returned to the side after a six-week absence with a broken hand.
Warrington?s youngsters made the most of their opportunity, with 18-year-old winger Chris Riley helping himself to two tries, while fellow 18-year-old forward Ben Harrison and Andy Bracek, 19, were also among the try-scorers.
The Wolves started by scoring over a point a minute as they crossed for four tries in the opening 18 minutes to lead 20-0.
Richie Barnett, Chris Bridge, Bracek and Reardon all touched down, with Bridge adding two conversions.
The wet conditions contributed to some poor handling from both sides and tempers also became frayed, which resulted in a brawl late in the first half which saw Bridge and London prop Alan Barker sent to the sin-bin for fighting.
The Wolves added two further tries in the final eight minutes of the half as Riley went over on both occasions to give the home side a 28-0 half-time advantage.
The Wolves added a further four tries in the second half to complete the half-century of points. Harrison, Mark Gleeson, Danny Lima and Steve Pickersgill all added to London?s misery, with Bridge finishing with four goals and stand-in skipper Paul Noone also adding two conversions.
The Skolars earned a well-deserved ovation from the home fans for their efforts, but the closest they came to scoring was when Shaun Ata was held up over the Warrington line in the first half.
Warrington 52 London Skolars 0
Tries: Ben Harrison, Chris Riley 2, Chris Bridge, Stuart Reardon, Andy Bracek, Michael Sullivan, Mark Gleeson, Steve Pickersgill, Richie Barnett Goal: Paul Noone 2, Chris Bridge 4
Warrington: Reardon, Riley, Kohe-Love, Grose, Barnett, Bridge, Sullivan, Lima, M. Gleeson, Pickersgill, Westwood, Noone, Bracek. Replacements: Parker, Cooper, Harrison, Grix.
London Skolars: Tozer, Simms, Shears, Ata, Aggrey, Garden, Meischke, Barker, Honor, Wallace, Castle, Pitman, Joyce. Replacements: Reid, Ellison, Fell, Jonker.
Referee: Jamie Leahy (Dewsbury) Att: 3,012Like