Brett Howland will start on the right wing for the Australian champions while Trent Waterhouse takes over in the pack from the departed Scott Sattler.
Luke Lewis comes in for an unavailable Ryan Girdler at centre and Colin Ward makes the bench.
"We're pretty fortunate to have as close to our Grand Final side as we have," said Panthers coach John Lang. "Obviously Girdler is a loss but I don't think we can complain too much," Lang added.
"We've been focusing on this game ever since we got back to training on 5 January.
"We came here early to make sure we're 100% over the jet lag and to acclimatise to the conditions."
Girdler misses out on the match at Huddersfield's McAlpine Stadium because of a lung illness.
Colin Ward, who has remained in training specifically for the showdown with Bradford, will officially retire from the sport after the match.
The run on side for Penrith:
Rhys Wesser Brett Howland Luke Lewis Paul Whatuira Luke Rooney Preston Campbell Craig Gower (c) Joel Cinton Luke Priddis Martin Lang Joe Galuvao Tony Puletua Trent Waterhouse.
Ben Ross Colin Ward Shane Rodney Luke SwainLike