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Powergen Challenge Cup holders Hull will begin the defence of their trophy in a blockbuster of a game against Engage Super League champions Bradford Bulls.
The clash of the trophy winners is the glamour tie of the fourth-round draw, which was made in Leeds on Monday night. The other all Super League game sees Wakefield Wildcats hosting Wigan Warriors.
League leaders St Helens were installed as favourites with after being drawn at home to National League side Doncaster while Leeds are second favourites after being paired with Leigh.
The rank outsiders are amateur side Thornhill Trojans, who caused the big upset in the third-round ties, and face a trip to France against the struggling Super League newcomers Catalans Dragons.
The prize for the two finalist is a day out in London at the new Wembley Stadium which, hopefully be open for this August's showpiece.
Featherstone v West Bowling or Keighley
Catalans Dragons v Thornhill Trojans
Swinton or Sheffield Eagles v Ovenden or York
Hunslet v Hull KR
Batley v Whitehaven
Widnes v Castleford
St Helens v Doncaster
Warrington v London Skolars
Harlequins v Toulouse
Widnes St Maries or Barrow v Oldham
Rochdale v Celtic Crusaders
Kells or Halifax v Huddersfield
Wakefield v Wigan
Bradford v Hull
Leigh v Leeds
Salford v Dewsbury
Ties to be played on the weekend of April 1-2