The NSW Blues have been named for the first game of the 2017 #Origin series.
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Radford, at 27, is the oldest player in a squad which includes two teenagers and whose average age is just 22.
"There is a great amount of young English talent in our game," Cullen told a news conference in Leeds.
"Super League is a lot healthier than some people might credit it for. When we went through the selection process, we had many names in every single position to consider.
"This 19-man squad has changed many times and we don?t think it?s been weakened by the fact players have been promoted from it into the Great Britain squad.
"It?s an England side with a point to prove, which is they all want to play for Great Britain in the World Cup in 2008."
Wakefield Trinity Wildcats centre Ryan Atkins will join the team once he has recovered from a hand injury while the squad could be boosted for follow9ing games by players discarded from the Great Britain party, currently in Australia preparing for Friday?s Tri-Nations warm-up game in Newcastle.
Cullen will name his captain when the squad go into camp on Thursday.
Chris Ashton ? Wigan Warriors
Ryan Bailey ? Leeds Rhinos
Mark Calderwood ? Wigan Warriors
Matt Cook ? Bradford Bulls
Paul Cooke ? Hull FC
Eorl Crabtree ? Huddersfield Giants
Matt Diskin ? Leeds Rhinos
Ewan Dowes ? Hull FC
Brett Ferres ? Bradford Bulls
Ashley Gibson ? Leeds Rhinos
Graeme Horne ? Hull FC
Jamie Jones Buchanan ? Leeds Rhinos
Rob Purdham ? Harlequins RL
Lee Radford ? Hull FC
Jamie Rooney ? Wakefield Trinity Wildcats
Lee Smith ? Leeds Rhinos
Nick Scruton ? Leeds Rhinos
Richard Whiting ? Hull FC
Danny Williams ? Leeds Rhinos