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Leeds welcome back Jamie Peacock and Chev Walker as they face Warrington in the first elimination play-off ahead of next month's Grand Final.
The pair were both rested last week as the third-placed Rhinos ran riot against the Catalans Dragons.
Warrington, who finished in sixth place, are chasing a first-ever semi-final place.
They welcome back Stuart Reardon after a stomach problem but Chris Leikvoll is out with a calf injury.
Stand-off Danny McGuire says Leeds hope to copy Bradford's route to Grand Final glory in 2005.
A year ago, the Bulls finished third in the table but went on to create history by defeating the Rhinos in the Grand Final at Old Trafford.
"It's been proven that a team from outside the top two can go on and do it," said Rhinos stand-off McGuire, who returned from a six-week absence with shin splints last weekend.
"We've had a few people writing us off and there is a little bit of motivation there for us. We're quietly confident we can do a job.
"It's a mini cup competition now. We can't afford to lose a game and we need three wins to get to the final.
"Last year we got to two finals and lost them both and this year we lost a semi-final. We seem to be just not performing in those big games and that's what we will be looking to do in these next few weeks.
"There is nothing worse than getting close and having it taken away from you," he said.
Leeds v Warrington, Friday, 22 September Headingley, Kick-off: 2000 BST Live commentary on Five Live Sports Extra and the BBC Sport website.
Leeds 18-man squad: Donald, Walker, Senior, McGuire, Burrow, Bailey, Diskin, Peacock, Lauitiiti, Ellis, Sinfield, Millard, Jones-Buchanan, Scruton, Kirke, Tansey, Thackray, Toopi
Warrington 18-man squad: Fa'afili, Martin Gleeson, Kohe-Love, Reardon, Briers, Sullivan, Swann, Wainwright, Mark Gleeson, Westwood, Wood, Barnett, Parker, Rauhihi, Pickersgill, Riley, Bridge, Penny