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St Helens welcome back centre Willie Talau from suspension but will go into their first home game without second-row pair Jon Wilkin, who starts a two-match ban, and Lee Gilmour, who has a broken nose.
Coach Daniel Anderson has included Paul Wellens and Ian Hardman, who have both been struggling with leg injuries, in his 18-man squad and one of them will take on the full-back role from Leon Pryce.
Harlequins RL start the campaign without last year